HCID 23125702, compound → HCID 23125718, compound

HRID 1820921Notes

Reaction equation

HRID 1820921 reaction equation
C([O:5][C:6](=[O:32])[CH2:7][CH2:8][NH:9][C:10]([NH:12][C:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[O:15][C:14]=1[C:22]([NH:24][C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=1)=[O:23])=[O:11])(C)(C)C>FC(F)(F)C(O)=O>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([NH:24][C:22]([C:14]2[O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:13]=2[NH:12][C:10]([NH:9][CH2:8][CH2:7][C:6]([OH:32])=[O:5])=[O:11])=[O:23])=[N:26][CH:27]=1

Participants

3

Reactant 1

HCID 23125702HCID 23125702, compound

Product 1

HCID 23125718HCID 23125718, compoundYield 104.6%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N-{[(2-{[(5-Chloropyridin-2-yl)amino]carbonyl}-benzofuran-3-yl)amino]carbonyl}-β-alanine t-butyl ester (1.71 g) obtained in Example 11(1) is dissolved in trifluoroacetic acid (15 ml), and the mixture is stirred at room temperature for 1 hour and 45 minutes. The reaction solution is concentrated in vacuo to reduce the volume by about half. To the residue is added diisopropyl ether and the precipitates are collected by filtration to give the title compound (1.57 g). ESI-MS M/Z:401/403[M−H]−

Workup

  1. concentrationThe reaction solution is concentrated in vacuo
  2. additionTo the residue is added diisopropyl ether
  3. filtrationthe precipitates are collected by filtration

Sources & evidence

ORD record
ord-3e6286bfc5694d739924a3c5d283ded5
Source dataset
uspto-grants-2009_10
Patent number
US07605158B2

Reaction notes

Loading…