反应详情

Glutaric anhydride (1.14 g) is dissolved in tetrahydrofuran (20 ml), and thereto is added morpholine (0.87 g). The mixture is then stirred at room temperature for 19 hours. The reaction solution is concentrated under reduced pressure, and the residue is diluted with chloroform and washed with 10% hydrochloric acid. The organic layer is dried over sodium sulfate and evaporated to remove the solvent under reduced pressure to give the title compound (1.05 g). ESI-MS M/Z:200[M−H]−

1. concentrationThe reaction solution is concentrated under reduced pressure
2. additionthe residue is diluted with chloroform
3. washwashed with 10% hydrochloric acid
4. dry with materialThe organic layer is dried over sodium sulfate
5. customevaporated
6. customto remove the solvent under reduced pressure