Sodium ion → 3-(2-Benzyloxy-ethoxymethyl)-4-(4-chloro-phenylsulfanyl)-5,8-difluoro-chroman

HRID 182111Notes

Reaction equation

HRID 182111 reaction equation
[Br:23][CH2:24][CH2:25][O:26][CH2:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:42][CH2:43][O:44][C:45](=[O:46])[CH3:47].[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8][CH:9]2[CH:10]([CH2:21][OH:22])[CH2:11][O:12][c:13]3[c:14]([F:20])[cH:15][cH:16][c:17]([F:19])[c:18]32)[cH:6][cH:7]1.[H-:35].[Na+:34].[OH2:36]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8][CH:9]2[CH:10]([CH2:21][O:22][CH2:24][CH2:25][O:26][CH2:27][c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)[CH2:11][O:12][c:13]3[c:14]([F:20])[cH:15][cH:16][c:17]([F:19])[c:18]32)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 73833Benzene, ((2-bromoethoxy)methyl)-HCID 166653HydrideHCID 67006433[4-(4-chlorophenyl)sulfanyl-5,8-difluoro-3,4-dihydro-2H-chromen-3-yl]methanol

Product 1

HCID 670064253-(2-Benzyloxy-ethoxymethyl)-4-(4-chloro-phenylsulfanyl)-5,8-difluoro-chroman

Sources & evidence

ORD record
ord-ed166f81118642eabc4325dc1954bd3d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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