反应详情

(1H-indazol-3-ylmethyl)triphenylphosphonium bromide (150 mg, 0.32 mmol) was dissolved in methanol (2 mL) and the solution was added with o-benzyloxybenzaldehyde (55 μL, 0.35 mmol) and potassium carbonate (88 mg, 0.63 mmol), followed by stirring at room temperature for 2 hours. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate solution, and extracted with ethyl acetate. Then, the organic layer was sequentially washed with water and saturated brine, and was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was triturated in a mixed solvent of ethyl acetate/hexane (2/1) to obtain Compound 13 (39.3 mg, 38%).

1. extractionextracted with ethyl acetate
2. washThen, the organic layer was sequentially washed with water and saturated brine
3. dry with materialwas dried over anhydrous magnesium sulfate
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was triturated in a mixed solvent of ethyl acetate/hexane (2/1)