Trifluoroacetic acid → HCID 68997636, compound

HRID 1821329Notes

Reaction equation

HRID 1821329 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:12]=[C:11]([C:13](=[O:32])[NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2/[CH:21]=[CH:22]/[C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[NH:25][N:24]=2)[N:10]([CH3:33])[CH:9]=1)(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>C(Cl)Cl>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[NH2:7][C:8]1[CH:12]=[C:11]([C:13]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2/[CH:21]=[CH:22]/[C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[NH:25][N:24]=2)=[O:32])[N:10]([CH3:33])[CH:9]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69002669HCID 69002669, compound

Product 1

HCID 68997636HCID 68997636, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(E)-(5-{2-[2-(1H-indazol-3-yl)vinyl]phenylcarbamoyl}-1-methyl-1H-pyrrol-3-yl) carbamic acid tert-butyl ester (15 mg, 0.033 mmol) was dissolved in methylene chloride (1.0 mL) and trifluoroacetic acid (100 μL) was added thereto followed by stirring at room temperature for 5 hours. Then, the mixture was concentrated and dried to obtain Compound 76 (11.3 mg, 96%).

Workup

  1. concentrationThen, the mixture was concentrated
  2. customdried

Sources & evidence

ORD record
ord-47710a98737b4d3484bb2e4c7b81a288
Source dataset
uspto-grants-2009_10
Patent number
US07605272B2

Reaction notes

Loading…