反应详情

温度

60 °C

Compound 28 (0.65 g, 0.62 mmol) was dissolved in dimethylacetamide and 0,4 g of compound 14 (1.2 mmol) was added to the reaction mixture as a solid. The reaction mixture was heated to 60° C. for 6 hours, then let cool to room temperature and 80 ml diethyl ether added and let stand for 3 days. The supernantant was decanted off leaving a dark brown residue, which was purified by flash silica chromatography (5 to 10% MeOH/CH2Cl2 then 5 to 10% MeOH/CH2Cl2 W/1% NH4OH) to give 0.45 g (0.37 mmol, 60%) of a yellow solid (compound 30).

1. temperaturelet cool to room temperature
2. customThe supernantant was decanted off
3. customleaving a dark brown residue, which
4. customwas purified by flash silica chromatography (5 to 10% MeOH/CH2Cl2