4-Methoxyphenol → HCID 12585423, compound

HRID 1821715Notes

Reaction equation

HRID 1821715 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[O:10]=[P:11](Cl)([Cl:13])[Cl:12]>CCOCC>[P:11]([Cl:13])([Cl:12])([O:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:10]

Participants

4

Reactant 2

HCID 90154-MethoxyphenolHCID 24813Phosphorus oxychloride

Product 1

HCID 12585423HCID 12585423, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

p-methoxyphenyl dichlorophosphate (11d) was prepared as described in Example 2 from p-methoxyphenol (4.00 g, 0.032 mol), POCl3 (3.00 mL, 0.032 mol) and TEA (4.49 mL, 0.032 mol) and dry Et2O (25 mL). The dichlorophosphate 11d was obtained as a yellow clear oil (5.1 g, 0.021 mol, 67%) and used without further purification.

Workup

  1. customp-methoxyphenyl dichlorophosphate (11d) was prepared

Sources & evidence

ORD record
ord-014bc727ed484c92b653119b642bbc52
Source dataset
uspto-grants-2009_10
Patent number
US07608599B2

Reaction notes

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