反应详情

温度

100 °C

To a stirred solution of 2-chloro-3,5-dimethyl pyrazine (1.0 mL; 8.3 mmol) in dimethylformamide (10 mL) was added sodium azide (539 mg; 8.3 mmol). The reaction was heated to 100° C. and stirred for 12 hours. The reaction was cooled to room temperature, diluted with 50 mL of ethyl acetate and washed with aqueous 10% sodium carbonate (1×50 mL), brine (50 mL), then dried (MgSO4) and filtered. The material was purified using a biotage 12L cartridge eluting with hexanes and ethyl acetate (3:1) to yield an off white solid (42% yield).

1. temperatureThe reaction was cooled to room temperature
2. washwashed with aqueous 10% sodium carbonate (1×50 mL), brine (50 mL)
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customThe material was purified
6. washeluting with hexanes and ethyl acetate (3:1)