反应详情

温度

60 °C

To a stirred solution of 3-azido-2,5-dimethyl pyrazine (100 mg; 0.66 mmol) in methanol (800 μL) was added 12N HCl (100 μL) and tin chloride dihydrate (149 mg; 0.66 mmol). The reaction was heated to 60° C. and stirred for 12 hours. The reaction was cooled to room temperature, diluted with 50 mL of ethyl acetate and washed with aqueous 10% sodium carbonate (1×50 mL), brine (50 mL), then dried (MgSO4) and filtered. The material was purified using a biotage 12i cartridge eluting with ethyl acetate to yield an off white solid (38% yield).

1. temperatureThe reaction was cooled to room temperature
2. washwashed with aqueous 10% sodium carbonate (1×50 mL), brine (50 mL)
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customThe material was purified
6. washeluting with ethyl acetate