HCID 57893442, compound → HCID 57893527, compound

HRID 1821886Notes

Reaction equation

HRID 1821886 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:11]2[NH:19][C:14]3=[CH:15][N:16]=[CH:17][CH:18]=[C:13]3[CH:12]=2)[OH:10])=[CH:5][CH:4]=1>O1CCCC1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[NH:19][C:14]3=[CH:15][N:16]=[CH:17][CH:18]=[C:13]3[CH:12]=2)=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 57893442HCID 57893442, compound

Product 1

HCID 57893527HCID 57893527, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(4-Methoxyphenyl)(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone (87 mg, 99%) was prepared as an off-white solid following the procedure described for Example 100 using (4-methoxyphenyl)(1H-pyrrolo[2,3-c]pyridin-2-yl)methanol (Example 99) and tetrahydrofuran as a solvent: mp 225-228° C.; 1H NMR (300 MHz, CD3OD) δ3.92 (3H, s), 7.10-7.19 (3H, m), 7.75-7.76 (1H, m), 8.02-8.06 (2H, m), 8.16 (1H, d, J=5.6 Hz), 8.86 (1H, s); ESI MS m/z 253 [C15H12N2O2+H]+; HPLC (Method A) >99% (AUC), tR=15.3 min.

Sources & evidence

ORD record
ord-c5b91f1c17e34504b609a3ec5cf5a5d9
Source dataset
uspto-grants-2009_10
Patent number
US07608627B2

Reaction notes

Loading…