HCID 57893523, compound → HCID 57893485, compound

HRID 1821887Notes

Reaction equation

HRID 1821887 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[NH:18][C:13]3=[CH:14][N:15]=[CH:16][CH:17]=[C:12]3[CH:11]=2)[OH:9])=[CH:4][CH:3]=1>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:10]2[NH:18][C:13]3=[CH:14][N:15]=[CH:16][CH:17]=[C:12]3[CH:11]=2)=[O:9])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 57893523HCID 57893523, compound

Product 1

HCID 57893485HCID 57893485, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(4-Chlorophenyl)(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone (108 mg, 67%) was prepared as a yellow solid following the procedure described for Example 100 using (4-chlorophenyl)(1H-pyrrolo[2,3-c]pyridin-2-yl)methanol (Example 101) and tetrahydrofuran as a solvent: mp 274-277° C. dec.; 1H NMR (300 MHz, CD3OD) δ7.21 (1H, s), 7.60-7.63 (2H, m), 7.73-7.76 (1H, m), 7.99-8.03 (2H, m), 8.16 (1H, d, J=5.6 Hz), 8.88 (1H, s); ESI MS m/z 257 [C14H9ClN2O+H]+; HPLC (Method A) >99% (AUC), tR=16.3 min.

Sources & evidence

ORD record
ord-2d1adbe24d94421a99e71eb8705901cc
Source dataset
uspto-grants-2009_10
Patent number
US07608627B2

Reaction notes

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