反应详情

2.07 g (42 mmol) pulverized, 88% potassium hydroxide, 3.0 g (0.021 mol) indole-5-carbonitrile and 0.68 g (2 mmol) tetrabutylammoniumbromide are jointly weighed out in the given order and mixed with 9.9 ml (126 mmol) epichlorohydrine with stirring. Stirring is continued overnight. Following hydrolysis and three extractions using ethyl acetate, the combined organic phases are washed three times with water. Drying of the organic phase using sodium sulfate and concentration of the solvent on the rotary evaporator leaves a solid which is purified on silica gel by column chromatography (flow agent: hexane/ethyl acetate 7:3).

1. stirringStirring
2. customhydrolysis and three extractions
3. washthe combined organic phases are washed three times with water
4. customDrying of the organic phase
5. customon the rotary evaporator
6. customleaves a solid which
7. customis purified on silica gel by column chromatography (flow agent: hexane/ethyl acetate 7:3)