Potassium Iodide → HCID 86602301, compound

HRID 1821972Notes

Reaction equation

HRID 1821972 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:29])[CH:5]=[C:6]([Cl:28])[C:7]=1[O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[C:23]([S:24][CH:25]([CH3:27])[CH3:26])=[N:22][N:21]=[N:20]2)=[CH:15][CH:14]=1.[Cl:30][C:31](Cl)([Cl:35])[CH2:32][CH2:33]Cl.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[Cl:28][C:6]1[CH:5]=[C:4]([O:29][CH2:33][CH:32]=[C:31]([Cl:35])[Cl:30])[CH:3]=[C:2]([Cl:1])[C:7]=1[O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([N:19]2[C:23]([S:24][CH:25]([CH3:27])[CH3:26])=[N:22][N:21]=[N:20]2)=[CH:17][CH:18]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 140561,1,1,3-TetrachloropropaneHCID 68538270HCID 68538270, compound

Product 1

HCID 86602301HCID 86602301, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

900 mg of 3,5-dichloro-4-{3-[4-(5-isopropylsulfanyl-tetrazol-1-yl)-phenoxy]-propoxy}-phenol, 720 mg of 1,1,1,3-tetrachloropropane, 691 mg of potassium carbonate and 10 mg of potassium iodide are stirred for 48 hours at 60° C. in 30 ml of acetone. The reaction mixture is filtered and the filtrate is concentrated. Purification over silica gel yields the title compound (compound 1.20).

Workup

  1. filtrationThe reaction mixture is filtered
  2. concentrationthe filtrate is concentrated
  3. customPurification over silica gel

Sources & evidence

ORD record
ord-5a2b823ad9ba4100a1c9bb66e3f5f602
Source dataset
uspto-grants-2009_10
Patent number
US07608631B2

Reaction notes

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