Potassium Carbonate → HCID 10390807, compound

HRID 1821977Notes

Reaction equation

HRID 1821977 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1.[Cl:13][C:14]1[CH:28]=[C:27]([O:29][CH2:30][CH:31]=[C:32]([Cl:34])[Cl:33])[CH:26]=[C:25]([Cl:35])[C:15]=1[O:16][CH2:17][CH2:18][CH2:19]OS(C)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:13][C:14]1[CH:28]=[C:27]([O:29][CH2:30][CH:31]=[C:32]([Cl:34])[Cl:33])[CH:26]=[C:25]([Cl:35])[C:15]=1[O:16][CH2:17][CH2:18][CH2:19][O:12][C:9]1[CH:8]=[CH:7][C:6]([N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1100644-(1,2,4-Triazol-1-yl)phenolHCID 86602295HCID 86602295, compound

Product 1

HCID 10390807HCID 10390807, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

125 mg of 4-[1,2,4]triazol-1-yl-phenol, 212 mg of methanesulfonic acid 3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propyl ester and 207 mg of potassium carbonate are stirred for 24 hours at 50° C. in 4 ml of dimethylformamide. The reaction mixture is poured onto water and extracted with ethyl acetate. Concentration of the organic phase and purification over silica gel yield the title compound (compound 1.9).

Workup

  1. additionThe reaction mixture is poured onto water
  2. extractionextracted with ethyl acetate
  3. customConcentration of the organic phase and purification over silica gel

Sources & evidence

ORD record
ord-c24f6126d5a84322b7d488870d209967
Source dataset
uspto-grants-2009_10
Patent number
US07608631B2

Reaction notes

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