反应详情

Combine 1-methyl-piperidine-4-thiol (1.4 g, 10.67 mmol) and N,N-dimethylformamide (10 mL) and cool to 0° C. Add 95% sodium hydride (0.28 g, 11.20 mmol), warm to ambient temperature and stir. After 40 min., add 1,3-difluoro-5-nitro-benzene (1.21 mL, 10.67 mmol), stir and heat at 65° C. After 3 hr., cool to ambient temperature and add water (50 mL). Extract with ethyl acetate (3×50 mL), wash combined organic layers with water (3×50 mL), aqueous NaCl solution (50 mL), dry organic layer over sodium sulfate, filter and concentrate. Purify residue by silica gel flash chromatography eluting with 10% (2M NH3/methanol)/methylene dichloride to obtain the title compound (0.31 g, 11%). Mass spectrum (electrospray): m/z=271.1 (M+1).

1. stirringstir
2. temperatureheat at 65° C
3. waitAfter 3 hr
4. temperature, cool to ambient temperature
5. extractionExtract with ethyl acetate (3×50 mL)
6. washwash
7. filtrationfilter
8. concentrationconcentrate
9. washPurify residue by silica gel flash chromatography eluting with 10% (2M NH3/methanol)/methylene dichloride