反应详情

A mixture of the 4-(diallylethoxysilyl)bromobenzene (152 mg, 0.49 mmol) obtained in Example 1, Pd(PPh3)4 (16.9 mg, 0.015 mmol), K2CO3 (101 mg, 0.73 mmol), and phenyl boronic acid (71.4 mg, 0.59 mmol) was added with dist.toluene (5 mL). Subsequently, the resultant mixture was stirred under a nitrogen atmosphere at 80° C. for 13 hours to obtain a reaction mixture. Thereafter, a salt formed in the reaction mixture was removed by filtering with celite. The solvent was distilled from the organic layer with an evaporator to obtain a crude product. After that, the crude product thus obtained was separated and purified by silica gel column chromatography (hexane/EtOAc=10/1), and thereby 4-(diallylethoxysilyl)biphenyl was obtained (91.2 mg, 61% yield).

1. additionwas added with dist
2. customto obtain a reaction mixture
3. customThereafter, a salt formed in the reaction mixture
4. customwas removed
5. filtrationby filtering with celite
6. distillationThe solvent was distilled from the organic layer with an evaporator
7. customto obtain a crude product
8. customAfter that, the crude product thus obtained
9. customwas separated
10. custompurified by silica gel column chromatography (hexane/EtOAc=10/1)