反应详情

To a solution of 3-benzyl-5-(3-nitrophenyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (98 mg, 0.25 mmol) in conc. hydrochloric acid (7 ml) was added tin chloride.2H2O (500 mg, 5-fold weights), and the mixture was stirred at room temperature for 1.5 hour, admixed with water, then treated with sodium carbonate to make it to pH8-9, and extracted with chloroform 8 times. The organic layer was dried over anhydrous magnesium sulfate, and evaporated to give 5-(3-aminophenyl)-3-benzyl-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one (63 mg, 70%).

1. extractionextracted with chloroform 8 times
2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
3. customevaporated