Benzenepropanal → HCID 178477499, compound

HRID 1822574Notes

Reaction equation

HRID 1822574 reaction equation
O=CCCc1ccccc1.CCSC(=O)C(NC(=O)c1ccccc1)C(=O)O>C1COCCN1.CN(C)c1ccncc1.C1CCOC1>CCSC(=O)/C(=C/CCc1ccccc1)NC(=O)c1ccccc1

Participants

6

Reactant 2

HCID 7707BenzenepropanalHCID 178477512HCID 178477512, compound

Product 1

HCID 178477499HCID 178477499, compoundYield 82%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 8083MorpholineCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
25 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-cf8d2459d9c24385af2e92ecc3b7c636
Source dataset
Bayesian optimization of 5 decarboxylative olefination reactions

Reaction notes

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