Paclitaxel → Sodium Chloride

HRID 1822676Notes

Reaction equation

HRID 1822676 reaction equation
COC1C=CC(C[C@H](O)C2C=C(OC)C(OC)=C(OC)C=2)=CC=1O.[CH3:25][C:26]1[C@@H:43]([O:44][C:45]([C@H:47]([OH:64])[C@@H:48]([NH:55][C:56]([C:58]2[CH:59]=[CH:60][CH:61]=[CH:62][CH:63]=2)=[O:57])[C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)=[O:46])[CH2:42][C@:38]2([OH:65])[C:39]([CH3:41])([CH3:40])[C:27]=1[C@@H:28]([O:83][C:84]([CH3:86])=[O:85])[C:29]([C@@:31]1([CH3:82])[C@H:36]([C@@H:37]2[O:66][C:67]([C:69]2[CH:70]=[CH:71][CH:72]=[CH:73][CH:74]=2)=[O:68])[C@:35]2([O:77][C:78]([CH3:80])=[O:79])[CH2:75][O:76][C@@H:34]2[CH2:33][C@@H:32]1[OH:81])=[O:30].O.[Na+:88].[Cl-:89]>C(O)C>[CH3:25][C:26]1[C@@H:43]([O:44][C:45]([C@H:47]([OH:64])[C@@H:48]([NH:55][C:56]([C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)=[O:57])[C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)=[O:46])[CH2:42][C@:38]2([OH:65])[C:39]([CH3:40])([CH3:41])[C:27]=1[C@@H:28]([O:83][C:84]([CH3:86])=[O:85])[C:29]([C@@:31]1([CH3:82])[C@H:36]([C@@H:37]2[O:66][C:67]([C:69]2[CH:74]=[CH:73][CH:72]=[CH:71][CH:70]=2)=[O:68])[C@:35]2([O:77][C:78]([CH3:80])=[O:79])[CH2:75][O:76][C@@H:34]2[CH2:33][C@@H:32]1[OH:81])=[O:30].[Na+:88].[Cl-:89]

Participants

6

Reactant 3

HCID 36314PaclitaxelHCID 100154222030-63-9HCID 57417360Sodium chloride; water

Product 2

HCID 5234Sodium ChlorideYield 0.9%HCID 36314Paclitaxel

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Drug administration: For administration to rodents, CA4P was dissolved in normal saline (0.9% NaCl). Paclitaxel was dissolved in a 50/50 mixture of ethanol and Cremophor® and stored at 4° C.; final dilution of paclitaxel was obtained immediately before drug administration with NaCl 0.9%. Fresh preparation of paclitaxel was employed to avoid precipitation. CPT-11 was dissolved in normal saline.

Workup

  1. customstored at 4° C.

Sources & evidence

ORD record
ord-0ca863e88c6047fea35bbf110b6bd8d2
Source dataset
uspto-grants-2006_05
Patent number
US07037906B1

Reaction notes

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