Acetate → Ethyl 6-[(4-chlorophenyl)methylcarbamoyl]-2-methoxy-8-methyl-5-oxo-1,8-naphthyridine-3-carboxylate

HRID 182283Notes

Reaction equation

HRID 182283 reaction equation
[C:45]([O-:46])(=[O:47])[CH3:48].[C:50]([O-:51])(=[O:52])[CH3:53].[CH3:27][CH2:28][OH:29].[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][C:8](=[O:9])[c:10]2[cH:11][n:12]([CH3:24])[c:13]3[n:14][c:15]([O:22][CH3:23])[c:16]([I:21])[cH:17][c:18]3[c:19]2=[O:20])[cH:25][cH:26]1.[Cl:42][CH2:43][Cl:44].[O:37]=[CH:38][N:39]([CH3:40])[CH3:41].[Pd+2:49]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][C:8](=[O:9])[c:10]2[cH:11][n:12]([CH3:24])[c:13]3[n:14][c:15]([O:22][CH3:23])[c:16]([C:38]([O:29][CH2:28][CH3:27])=[O:37])[cH:17][c:18]3[c:19]2=[O:20])[cH:25][cH:26]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 702EthanolHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 5276330N-[(4-chlorophenyl)methyl]-6-iodo-7-methoxy-1-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

Product 1

HCID 5276333Ethyl 6-[(4-chlorophenyl)methylcarbamoyl]-2-methoxy-8-methyl-5-oxo-1,8-naphthyridine-3-carboxylate

Sources & evidence

ORD record
ord-ff1b6c6b54354914a769e7a0963e93ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…