HCID 21920028, compound → 3-Fluoro-4-[(3-fluorophenyl)methoxy]benzenamine

HRID 1823007Notes

Reaction equation

HRID 1823007 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1>C(OCC)(=O)C.[Pt]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1

Participants

4

Reactant 1

HCID 21920028HCID 21920028, compound

Product 1

HCID 219200533-Fluoro-4-[(3-fluorophenyl)methoxy]benzenamineYield 98.1%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

12.68 g (47.8 mmol) 2-fluoro-1-(3-fluoro-benzyloxy)-4-nitro-benzene is dissolved in 150 ml ethyl acetate. 1.27 g platinum 5% on charcoal is added and the mixture is hydrogenated at RT and normal pressure for 6 hours. The catalyst is filtered off and the solution evaporated to yield 11.03 g (98%) of a dark brown liquid. MS: m/e=235.1 (M+).

Workup

  1. customis hydrogenated at RT
  2. filtrationThe catalyst is filtered off
  3. customthe solution evaporated

Sources & evidence

ORD record
ord-8ee0a8223c9e4c77bd7c9b0d7ba93900
Source dataset
uspto-grants-2006_05
Patent number
US07037935B2

Reaction notes

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