Tetrahydrofuran → 2-(4-Bromo-2-fluorophenylamino)-6-chloro-nicotinic acid

HRID 182308Notes

Reaction equation

HRID 182308 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:9])[c:5]([NH2:8])[cH:6][cH:7]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:10][Si:11]([N-:12][Si:13]([CH3:14])([CH3:15])[CH3:16])([CH3:17])[CH3:18].[Cl:20][c:21]1[c:22]([C:23](=[O:24])[OH:25])[cH:26][cH:27][c:28]([Cl:30])[n:29]1.[Li+:19]>>[Br:1][c:2]1[cH:3][c:4]([F:9])[c:5]([NH:8][c:21]2[c:22]([C:23](=[O:24])[OH:25])[cH:26][cH:27][c:28]([Cl:30])[n:29]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 1230504-Bromo-2-fluoroanilineHCID 8540472,6-Dichloronicotinic acidHCID 3280088Npc316347

Product 1

HCID 635290422-(4-Bromo-2-fluorophenylamino)-6-chloro-nicotinic acid

Sources & evidence

ORD record
ord-3e2a349b48494f94b8e91141f32c60d3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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