Ammonia → HCID 21964517, compound

HRID 1823751Notes

Reaction equation

HRID 1823751 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15](O)=[O:16])[CH:9]=[CH:10][CH:11]=1.C([N:26](CC)CC)C.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.N>CN(C=O)C>[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([NH2:26])=[O:16])[CH:9]=[CH:10][CH:11]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 9926783HCID 9926783, compound

Product 1

HCID 21964517HCID 21964517, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid (Step D) in DMF, add triethylamine and BOP, after couple of hours of stirring, reaction mixture can be added to liquid ammonia at 0° C. and the re suiting mixture can be warmed for 16 hours to give title compound

Workup

  1. customreaction mixture
  2. temperaturethe re suiting mixture can be warmed for 16 hours

Sources & evidence

ORD record
ord-d0eba3c51f01476f916c5a594699096f
Source dataset
uspto-grants-2006_05
Patent number
US07041659B2

Reaction notes

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