Hydrochloric Acid → HCID 67041144, compound

HRID 1823923Notes

Reaction equation

HRID 1823923 reaction equation
[CH3:1][O:2][C:3](=[O:17])[CH:4]([C:8]1[C:13]([F:14])=[CH:12][CH:11]=[C:10]([Cl:15])[C:9]=1[F:16])[CH2:5][C:6]#[N:7].Cl>CO.[Pt](=O)=O>[ClH:15].[CH3:1][O:2][C:3](=[O:17])[CH:4]([C:8]1[C:13]([F:14])=[CH:12][CH:11]=[C:10]([Cl:15])[C:9]=1[F:16])[CH2:5][CH2:6][NH2:7]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23570957HCID 23570957, compound

Product 1

HCID 67041144HCID 67041144, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-(3-Chloro-2,6-difluorophenyl)-3-cyanopropionic acid methyl ester (784 mg, 3.0 mmol) and concentrated hydrochloric acid (0.63 mL, 7.55 mmol) in MeOH (5 mL) was added platinum dioxide (69 mg, 0.3 mmol) under nitrogen. The reaction mixture was degassed (5× vacuum cycles) and the nitrogen atmosphere replaced with hydrogen (5× vacuum cycles). The mixture was stirred for 3.5 hours, then filtered through a pad of Celite®, washing with MeOH. The filtrate was concentrated and used in the next step without further purification.

Workup

  1. customThe reaction mixture was degassed (5× vacuum cycles)
  2. filtrationfiltered through a pad of Celite®
  3. washwashing with MeOH
  4. concentrationThe filtrate was concentrated
  5. customused in the next step without further purification

Sources & evidence

ORD record
ord-80f7a847f7b6417ab84baac593d48143
Source dataset
uspto-grants-2006_05
Patent number
US07041687B2

Reaction notes

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