反应详情

Ethylbromoacetate (4.17 g, 25 mmol) was added to a mixture of 4-benzyloxyphenol (5.00 g, 25 mmol) and K2CO3 (3.50 g, 25 mmol) in DMF (75 mL) and stirred for 20 hours at ambient temperature. The mixture was then concentrated in vacuo and the residue partitioned between water and EtOAc. The aqueous phase was further extracted with 2×50 mL of EtOAc and the combined extracts were washed with 2×50 mL of water and dried over Na2SO4. Concentration of the organic solution in vacuo left 7.00 g (97%) of product as a white solid. m.p. 65–68° C.

1. concentrationThe mixture was then concentrated in vacuo
2. customthe residue partitioned between water and EtOAc
3. extractionThe aqueous phase was further extracted with 2×50 mL of EtOAc
4. washthe combined extracts were washed with 2×50 mL of water
5. dry with materialdried over Na2SO4
6. waitConcentration of the organic solution in vacuo left 7.00 g (97%) of product as a white solid