Lithium Hydroxide → HCID 58632036, compound

HRID 1824427Notes

Reaction equation

HRID 1824427 reaction equation
C[O:2][C:3]([CH:5]1[N:9]2[C:10](=[O:17])[CH:11]([NH2:16])[CH2:12][CH2:13][CH2:14][CH2:15][CH:8]2[CH2:7][CH2:6]1)=[O:4].[Li+].[OH-]>C1COCC1.O>[NH2:16][C@@H:11]1[C:10](=[O:17])[N:9]2[C@H:5]([C:3]([OH:4])=[O:2])[CH2:6][CH2:7][C@@H:8]2[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 23571428HCID 23571428, compound

Product 1

HCID 58632036HCID 58632036, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

The crude 6-amino-5-oxo-decahydro-pyrrolo[1,2-a]azocine-3-carboxylic acid methyl ester, 18, obtained from the previous reaction is dissolved in a mixture of THF:water (3:1) (40 mL) and treated with a catalytic amount of LiOH. The reaction solution is allowed to stir overnight then concentrated in vacuo to afford the desired product which is used without further purification.

Workup

  1. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-7495393eba6f44888099bec7553c85c5
Source dataset
uspto-grants-2006_05
Patent number
US07041696B2

Reaction notes

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