反应详情

A solution of 5-chloro-2-(1-homopiperazinyl)-7-methylbenzoxazole (2.5 g) in ethyl acetate (75 mL) was added dropwise with a separately prepared methanesulfonic acid/methanol solution [prepared by adding methanol to methanesulfonic acid (0.61 mL) to a total volume of 12.5 mL] at room temperature with stirring. After the addition, the mixture was stirred for 1 hour at room temperature and for 1 hour with ice cooling, and the produced colorless precipitates were collected by filtration. The precipitates were dried under reduced pressure at 4 C.° for 5 hours to obtain the title compound (3.0 g).

1. customprepared
2. additionAfter the addition
3. stirringthe mixture was stirred for 1 hour at room temperature and for 1 hour with ice cooling
4. customthe produced colorless precipitates
5. filtrationwere collected by filtration
6. customThe precipitates were dried under reduced pressure at 4 C.° for 5 hours