反应详情

To 2-chloro-4-methoxy-benzoic acid methyl ester (1.1 g) in THF/MeOH/water (12 mL/3 mL/3 mL) at room temperature was added LiOH (461 mg) dissolved in water. After 2 h, the reaction mixture was adjusted to pH 4 with 1N HCl and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried over MgSO4. Trituration of the resulting solid in ether afforded 1.0 g (98%) of the title compound. MS: 187 (MH+), HPLC tR: 2.04 min.

1. custompartitioned between ethyl acetate and water
2. washThe organic layer was washed with brine
3. dry with materialdried over MgSO4