反应详情

温度

150 °C

To 7-bromo-5-methoxy-2-(4-methoxy-phenyl)-benzooxazole (200 mg) in DMF (5 mL) was added CuCN (80 mg). The mixture was placed in an oil bath and heated to 150° C. for 3 h. The mixture was cooled to room temperature and diluted with ethyl acetate and washed with 1N HCl, brine (3×), dried (Na2SO4), and concentrated. Flash chromatography on silica gel eluting with 20% ethyl acetate-hexane afforded 85 mg (50%) of the title compound as a solid. MS: 281 (MH+), HPLC tR: 2.71 min.

1. customThe mixture was placed in an oil bath
2. temperatureThe mixture was cooled to room temperature
3. washwashed with 1N HCl, brine (3×)
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated