Hydrochloric Acid → HCID 22144673, compound

HRID 1824981Notes

Reaction equation

HRID 1824981 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([C:17]2[N:18]([CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=3[F:43])[C:19]3[C:24]([CH:25]=2)=[CH:23][C:22]([NH:26][C:27](=[O:35])[CH2:28][CH:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[CH:21][CH:20]=3)=[O:16])=[CH:10][CH:9]=1)(C)(C)C.[ClH:45]>O1CCOCC1>[ClH:45].[NH2:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][C:15]([C:17]2[N:18]([CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=3[F:43])[C:19]3[C:24]([CH:25]=2)=[CH:23][C:22]([NH:26][C:27](=[O:35])[CH2:28][CH:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[CH:21][CH:20]=3)=[O:16])=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23573458HCID 23573458, compound

Product 1

HCID 22144673HCID 22144673, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

121 mg (0.20 mmol) of tert-butyl-4-[({1-(2-fluorobenzyl)-5-[(tetrahydro-2H-pyran-4-ylacetyl)amino]-1H-indol-2-yl}carbonyl)amino]phenylcarbamate from Example XXXIII, 1.40 ml of dioxane and 1.40 ml of conc. hydrochloric acid are combined and stirred at RT for one hour. The mixture is evaporated to dryness using a rotary evaporator.

Workup

  1. customThe mixture is evaporated to dryness
  2. customa rotary evaporator

Sources & evidence

ORD record
ord-e333b5be9bfc4f38beb2c7b5a9538fc7
Source dataset
uspto-grants-2006_05
Patent number
US07045544B2

Reaction notes

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