反应详情

27.84 g (81.33 mmol) of ethyl 1-(2-fluorobenzyl)-5-nitro-1H-indole-2-carboxylate from Example II are initially charged in 750 ml of ethyl acetate and 750 ml of ethanol. 20.51 g (325.31 mmol) of ammonium formate and 2.78 g of palladium on activated carbon are added. The mixture is boiled at reflux and, after one hour, cooled and filtered off through kieselguhr. The filter cake is washed with ethyl acetate. The solvent is removed under reduced pressure and the residue is dried.

1. temperatureat reflux and, after one hour
2. temperaturecooled
3. filtrationfiltered off through kieselguhr
4. washThe filter cake is washed with ethyl acetate
5. customThe solvent is removed under reduced pressure
6. customthe residue is dried