反应详情

温度

90 °C

105 mg (0.26 mmol) of ethyl 5-[(3,3-dimethylbutanoyl)amino]-1-[2-(trifluoromethyl)benzyl]-1H-indole-2-carboxylate from Example LXIII are dissolved in 1 ml each of methanol and THF, and 0.26 ml (0.52 mmol) of 2M lithium hydroxide solution is added. The mixture is heated at 90° C. for one hour. After cooling, the mixture is, for work-up, diluted and extracted with aqueous hydrochloric acid and ethyl acetate. The organic phase is dried with sodium sulphate, filtered and dried under reduced pressure.

1. temperatureAfter cooling
2. additiondiluted
3. extractionextracted with aqueous hydrochloric acid and ethyl acetate
4. dry with materialThe organic phase is dried with sodium sulphate
5. filtrationfiltered
6. customdried under reduced pressure