Hydrochloric Acid → HCID 69593507, compound

HRID 1825038Notes

Reaction equation

HRID 1825038 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[CH:12]=1)[CH2:9][OH:10])(C)(C)C.[ClH:25]>CO>[ClH:25].[NH2:7][C@H:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[CH:12]=1)[CH2:9][OH:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58633267HCID 58633267, compound

Product 1

HCID 69593507HCID 69593507, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(R)-[2-Hydroxy-1-(3-morpholin-4-ylmethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester (2.1 g, 6.25 mmol) in methanol (22 mL) was added hydrochloric acid (2.0M in ethyl ether) (10.88 mL, 21.8 mmol) and reaction mixture was stirred at room temperature for 5 hr. The reaction mixture was concentrated under vacuum to provide the title compound as a pale green solid (quantitative yield).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-60310fcc01c542e6a20ea5ff3487eb86
Source dataset
uspto-grants-2006_05
Patent number
US07045551B2

Reaction notes

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