反应详情

A mixture of (R)-2-amino-2-naphthalen-2-yl-ethanol (0.2 mmol), 2-fluorocinnamic acid (0.2 mmol), EDC HCl (0.4 mmol), DMAP (0.2 mmol), triethyl amine (0.6 mmol) in dichloromethane (4 mL) was stirred at room temperature for 14 h. The reaction mixture was purified by flash chromatography with 50% ethyl acetate in hexanes to provide the desired product (56 mg) as a solid.

1. customThe reaction mixture was purified by flash chromatography with 50% ethyl acetate in hexanes