反应详情

4-Cyanobenzaldehyde (1.98 g, 0.015 mol) was added to a mixture of 2H-1,4-benzoxazin-3(4H)-one (1.49 g, 0.01 mol), acetic anhydride (4 ml) and triethylamine (2 ml). The reaction mixture was refluxed for 7 h, left overnight at room temperature and poured into crushed ice. The precipitated solid was collected by filtration and washed with acetonitrile. The crude product was purified by recrystalization from DMF:ethanol.

1. temperatureThe reaction mixture was refluxed for 7 h
2. additionpoured
3. custominto crushed ice
4. filtrationThe precipitated solid was collected by filtration
5. washwashed with acetonitrile
6. customThe crude product was purified by recrystalization from DMF