Tetrahydrofuran → 7-bromo-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine

HRID 182584Notes

Reaction equation

HRID 182584 reaction equation
[Al+3:22].[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:20]1)[C:7]([c:13]1[c:14]([F:19])[cH:15][cH:16][cH:17][cH:18]1)=[N:8][CH2:9][C:10](=[O:12])[NH:11]2.[H-:21].[H-:24].[H-:25].[H-:26].[Li+:23].[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:20]1)[C:7]([c:13]1[c:14]([F:19])[cH:15][cH:16][cH:17][cH:18]1)=[N:8][CH2:9][CH2:10][NH:11]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 129470247-Bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Product 1

HCID 577324247-bromo-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine

Sources & evidence

ORD record
ord-4057a7c6e074448380e56f7dd8eba110
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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