反应详情

A fully reacted mixture of equimolar amounts of diethyl azodicarboxylate and triphenylphosphine in THF is admixed with equimolar amounts of 4.9 g of 4-(5-undecyl-pyrimidin-2-yl)phenol and 5-ethyl-furan-2-yl-methanol (prepared by LiAlH4 reduction of methyl 5-ethyl-furan-2-carboxylate, which in turn can be obtained by esterification of 5-ethyl-furan-2-carboxylic acid from Example 1). The mixture is stirred for 24 h at room temperature and then evaporated to dryness under reduced pressure. Purification by chromatography (silica gel, dichloromethane) and recrystallization affords the target compound.

1. customevaporated to dryness under reduced pressure
2. customPurification
3. customby chromatography (silica gel, dichloromethane) and recrystallization
4. customaffords the target compound