4-(Piperidin-4-yl)indolin-2-one → HCID 69584198, compound

HRID 1826784Notes

Reaction equation

HRID 1826784 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][C:10](=[O:16])[NH:11]3)[CH2:3][CH2:2]1.[O:17]=[C:18]1[CH2:22][CH2:21][CH2:20][N:19]1[CH2:23][CH2:24][CH2:25][NH:26][C:27]([C:29]1[C:33]([CH3:34])=[C:32]([CH:35]=O)[NH:31][CH:30]=1)=[O:28]>N1CCCCC1.C(O)C>[O:17]=[C:18]1[CH2:22][CH2:21][CH2:20][N:19]1[CH2:23][CH2:24][CH2:25][NH:26][C:27]([C:29]1[C:33]([CH3:34])=[C:32]([CH:35]=[C:9]2[C:8]3[C:12](=[CH:13][CH:14]=[CH:15][C:7]=3[CH:4]3[CH2:3][CH2:2][NH:1][CH2:6][CH2:5]3)[NH:11][C:10]2=[O:16])[NH:31][CH:30]=1)=[O:28]

Participants

5

Reactant 2

HCID 221353964-(Piperidin-4-yl)indolin-2-oneHCID 86586558HCID 86586558, compound

Product 1

HCID 69584198HCID 69584198, compound

Reagents, catalysts & solvents 2

HCID 8082PiperidineCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-piperidin-4-yl-1,3-dihydroindol-2-one (35.6 mg, 0.165 mmol), 5-formyl-4-methyl-1H-pyrrole-3-carboxylic acid [3-(2-oxo-pyrrolidin-1-yl)propyl]-amide (48 mg, 0.173 mmol) and piperidine (2 drops) in ethanol (0.5 mL) was stirred at room temperature for 7 days. The reaction was concentrated and ether was added to the residue. The precipitate which formed was collected by vacuum filtration, washed with ethanol and ether and dried to give the title compound.

Workup

  1. concentrationThe reaction was concentrated
  2. additionether was added to the residue
  3. customThe precipitate which formed
  4. filtrationwas collected by vacuum filtration
  5. washwashed with ethanol and ether
  6. customdried

Sources & evidence

ORD record
ord-beb661d55a2847c39c74dd1865e80134
Source dataset
uspto-grants-2006_05
Patent number
US07053086B2

Reaction notes

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