HRID1826795

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID8082

Piperidine

C5H11N

HCID22135397

未命名化合物

结构：CCOC(=O)c1c(C)[nH]c(C=O)c1CCCN1CCN(C)CC1

HCID58779587

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3cccc(-c4cncc(C(=O)O)c4)c32)c1CCCN1CCN(C)CC1

HCID69584084

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度: 60 °C

PROCEDURE

实验过程

A mixture of 5-(2-oxo-2,3-dihydro-1H-indol-4-yl)-nicotinic acid (51 mg, 0.2 mmol), 5-formyl-2-methyl-4-[3-(4-methyl-piperazin-1-yl)-propyl]-1H-pyrrole-3-carboxylic acid ethyl ester (64 mg, 0.2 mmol) and piperidine (0.2 mL) in ethanol (1 mL) was heated in a sealed tube at 60° C. for 5 hours. The reaction was acidified with 1N HCl and the resulted precipitate was collected by vacuum filtration, washed with water and dried to give the title compound.

WORKUP

后处理

filtrationthe resulted precipitate was collected by vacuum filtration
washwashed with water
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6e6f8ec4045349cfb1878a25bc087a52
来源数据集: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07053086B2
来源说明: uspto-grants-2006_05

反应 SMILES

[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[C:11]2[CH:12]=[N:13][CH:14]=[C:15]([CH:19]=2)[C:16]([OH:18])=[O:17])[NH:3]1.[CH2:20]([O:22][C:23]([C:25]1[C:29]([CH2:30][CH2:31][CH2:32][N:33]2[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]2)=[C:28]([CH:40]=O)[NH:27][C:26]=1[CH3:42])=[O:24])[CH3:21].N1CCCCC1.Cl>C(O)C>[CH2:20]([O:22][C:23]([C:25]1[C:29]([CH2:30][CH2:31][CH2:32][N:33]2[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]2)=[C:28]([CH:40]=[C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][C:8]=3[C:11]3[CH:12]=[N:13][CH:14]=[C:15]([CH:19]=3)[C:16]([OH:18])=[O:17])[NH:3][C:2]2=[O:1])[NH:27][C:26]=1[CH3:42])=[O:24])[CH3:21]