Trifluoroacetic acid → Trifluoroacetate

HRID 1827245Notes

Reaction equation

HRID 1827245 reaction equation
[C:1]1([C@@H:7]2[CH2:9][C@H:8]2[C:10]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][NH:19]C(=O)OC(C)(C)C)[CH2:14][CH2:13]2)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>C(Cl)Cl>[C:1]1([C@@H:7]2[CH2:9][C@H:8]2[C:10]([N:12]2[CH2:13][CH2:14][CH:15]([CH2:18][NH2:19])[CH2:16][CH2:17]2)=[O:11])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[F:30][C:29]([F:32])([F:31])[C:27]([O-:33])=[O:28]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58635339HCID 58635339, compound

Product 2

HCID 84468TrifluoroacetateHCID 58635332HCID 58635332, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl (1-{[(1R,2R)-2-phenylcyclopropyl]carbonyl}piperidin-4-yl)methylcarbamate (1.00 g, 2.79 mmol) in TFA (3 mL) and CH2Cl2 (3 mL) was stirred at R.T. for 0.5 h. The reaction mixture was then concentrated to give the title compound as a trifluoroacetate salt.

Workup

  1. concentrationThe reaction mixture was then concentrated

Sources & evidence

ORD record
ord-22137ea8beca4eb68c637e5c925a4b41
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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