1,2-Dichloroethane → HCID 21098384, compound

HRID 1827253Notes

Reaction equation

HRID 1827253 reaction equation
C(O[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]2[C:24]([F:25])=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:13][CH2:12]1)=[O:10])C1C=CC=CC=1.[CH2:26](Cl)[CH2:27]Cl.[CH:30]1[CH:31]=[CH:32][C:33]2N(O)N=N[C:34]=2[CH:35]=1.[CH3:40]N(C=O)C>>[F:25][C:24]1[C:19]([NH:18][CH2:17][CH:14]2[CH2:13][CH2:12][N:11]([C:9]([C@@H:27]3[CH2:26][C@H:40]3[C:34]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:35]=3)=[O:10])[CH2:16][CH2:15]2)=[N:20][CH:21]=[CH:22][CH:23]=1

Participants

5

Reactant 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 23577267HCID 23577267, compound

Product 1

HCID 21098384HCID 21098384, compound

Procedure

Prepared from 4-[(3-fluoro-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester by hydrogenolysis of the benzyloxycarbonyl group followed by EDC, HOBt coupling with [R,R] trans-2-phenyl-1-cyclopropanecarboxylic acid in DMF in the usual manner such as described previously in EXAMPLE 143 above:

Sources & evidence

ORD record
ord-f295b536670d4a1d8ed6bf7b81588616
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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