HCID 21920028, compound → 3-Fluoro-4-[(3-fluorophenyl)methoxy]benzenamine

HRID 1827370Notes

Reaction equation

HRID 1827370 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N+:17]([O-])=O)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1>C(OCC)(=O)C.[Pt]>[F:1][C:2]1[CH:3]=[C:4]([NH2:17])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1

Participants

4

Reactant 1

HCID 21920028HCID 21920028, compound

Product 1

HCID 219200533-Fluoro-4-[(3-fluorophenyl)methoxy]benzenamineYield 98.1%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

12.68 g (47.8 mmol) of 3-fluoro-4-(3-fluoro-benzyloxy)-nitrobenzene in 150 ml ethyl acetate is treated with 1.27 g of 5% platinum on charcoal and hydrogenated for 6 h at room temperature and normal pressure. The catalyst is filtered and the solution evaporated to yield 11.03 g (98%) of dark brown oil. MS: m/e=235.1 (M+).

Workup

  1. filtrationThe catalyst is filtered
  2. customthe solution evaporated

Sources & evidence

ORD record
ord-1f746806aded4b4c858d7d08b971c567
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

Loading…