Hydrochloric Acid → HCID 131725779, compound

HRID 1827530Notes

Reaction equation

HRID 1827530 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[S:10]([N:13]([C:28]1[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][N:37]2[CH2:41][CH2:40][CH2:39][CH2:38]2)=[CH:30][CH:29]=1)[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21]C2CCCCO2)=[CH:17][CH:16]=1)(=[O:12])=[O:11].[ClH:42]>CO>[ClH:42].[OH:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][N:13]([C:28]2[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][N:37]3[CH2:38][CH2:39][CH2:40][CH2:41]3)=[CH:30][CH:29]=2)[S:10]([C:3]2[C:4]([CH3:9])=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=2[CH3:1])(=[O:12])=[O:11])=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22137326HCID 22137326, compound

Product 1

HCID 131725779HCID 131725779, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2,4,6-Trimethyl-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-N-[4-(tetrahydro-pyran-2-yloxy)-benzyl]-benzenesulfonamide was dissolved in methanol (30 mL) and 1N HCl (5 mL) was added. The reaction mixture was stirred for 30 minutes at room temperature and was concentrated in vacuo. The residue was triturated with methylene chloride followed by ether to obtain the title compound as the HCl salt. MS 495.4 (M+1)+

Workup

  1. concentrationwas concentrated in vacuo
  2. customThe residue was triturated with methylene chloride

Sources & evidence

ORD record
ord-432d83f3aaae4c6ba9a7cf64311e9b23
Source dataset
uspto-grants-2006_05
Patent number
US07053212B2

Reaction notes

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