Hydrochloric Acid → HCID 131725780, compound

HRID 1827535Notes

Reaction equation

HRID 1827535 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=2)[C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:14][CH:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl>CO.CCOCC>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:26][C:27]2[CH:28]=[CH:29][C:30]([OH:33])=[CH:31][CH:32]=2)[C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:16][CH:17]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10005668HCID 10005668, compound

Product 1

HCID 131725780HCID 131725780, compoundYield 197.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 4-chloro-N-(4-hydroxy-benzyl)-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]benzenesulfonamide (0.016 g, 32.9 μmol) in methanol (1 mL) was added HCl as a 1M solution in ether (0.045 ml). The reaction mixture was stirred at room temperature for 1 hr., and then concentrated in vacuo to give the title compound (0.017 g, 32.5 μmol).

Workup

  1. concentration, and then concentrated in vacuo

Sources & evidence

ORD record
ord-b8bc10e7ba894e0eb682844518d345e6
Source dataset
uspto-grants-2006_05
Patent number
US07053212B2

Reaction notes

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