HCID 22091412, compound → HCID 22091413, compound

HRID 1827833Notes

Reaction equation

HRID 1827833 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]([C:39]#[N:40])([NH:12][C:13](=[O:38])[CH:14]([NH:22][C:23]([CH:25]2[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]2)=[O:24])[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]>Cl.O1CCOCC1>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][C:9]([C:39]#[N:40])([NH:12][C:13](=[O:38])[CH:14]([NH:22][C:23]([CH:25]2[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]2)=[O:24])[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 22091412HCID 22091412, compound

Product 1

HCID 22091413HCID 22091413, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The ester from (a) was dissolved in 10 mL of 4 N HCl in 1,4-dioxane at 0° C. for 1 hour. The solution was concentrated in vacuo and the salt neutralized by sodium bicarbonate solution and the product extracted with CH2Cl2. After concentration of the organic extract, the crude product was purified by reverse-phase HPLC to yield the desired product; MS, m/z 462=M+1.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. extractionthe product extracted with CH2Cl2
  3. customAfter concentration of the organic extract, the crude product was purified by reverse-phase HPLC

Sources & evidence

ORD record
ord-5a55149203ac4077b7b9365b93f6703e
Source dataset
uspto-grants-2006_06
Patent number
US07056915B2

Reaction notes

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