反应详情

To a stirred solution of 4-chloro-2-(1H-pyrazol-3-yl)-phenol (1 g, CAS 18704-67-1) at r.t. in acetone (20 ml) under an argon atmosphere were added K2CO3 (746 mg) and benzylbromid (0.61 ml). The reaction mixture was stirred at r.t. for 21 h. The solids were filtered off and washed with acetone. The filtrate was concentrated to leave a light orange oil. The crude product was purified by chromatography (silica gel, cyclohexane/ethyl acetate 2:1) to give 3-(2-benzyloxy-5-chloro-phenyl)-1H-pyrazole as off-white solid. MS 284.8 ([M+H]+)

1. filtrationThe solids were filtered off
2. washwashed with acetone
3. concentrationThe filtrate was concentrated
4. customto leave a light orange oil
5. customThe crude product was purified by chromatography (silica gel, cyclohexane/ethyl acetate 2:1)