反应详情

温度

60 °C

A mixture of (RS)-N-(4-cyano-benzyl)-2-ethoxy-malonamic acid ethyl ester (1.97 g) and LiOH (285 mg) in MeOH (14 ml), H2O (7 ml) and THF (14 ml) was stirred 3 h at 60° C. The solvents were evaporated, EtOAc was added and it was washed with HCl 0.1 N, water and brine. The aqueous phases were extracted again with more EtOAc. The combined organic phases were dried (MgSO4) and the solvent was removed to yield (RS)-N-(4-cyano-benzyl)-2-ethoxy-malonamic acid, 1.53 g (86%); of white solid. MS 260.2 (100, [M+H]+), 277.2 (13, [M+NH4]+)

1. customThe solvents were evaporated
2. additionEtOAc was added
3. washit was washed with HCl 0.1 N, water and brine
4. extractionThe aqueous phases were extracted again with more EtOAc
5. dry with materialThe combined organic phases were dried (MgSO4)
6. customthe solvent was removed