Hydrochloric Acid → HCID 11097732, compound

HRID 1828255Notes

Reaction equation

HRID 1828255 reaction equation
O.[OH-].[Li+].[CH3:4][N:5]([CH3:22])[S:6]([C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[C:18]([O:20]C)=[O:19])(=[O:8])=[O:7].Cl>CO.O>[CH3:4][N:5]([CH3:22])[S:6]([C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=1[C:18]([OH:20])=[O:19])(=[O:8])=[O:7]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 22066003HCID 22066003, compound

Product 1

HCID 11097732HCID 11097732, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

60.2 g of lithium hydroxide monohydrate are added to a solution of 206.7 g of N,N-dimethyl-2-methoxycarbonyl-5-nitrobenzenesulfonamide in 1500 ml of methanol. The mixture is subsequently stirred at 50° C. until conversion is complete. Following the concentration of the reaction mixture under reduced pressure, the residue is taken up in water and is treated at 0° C. with concentrated hydrochloric acid (pH=1). Filtration with suction followed by drying gives the desired compound. Yield: 162.9 g; m.p.: 160–163° C.

Workup

  1. filtrationFiltration with suction
  2. customby drying

Sources & evidence

ORD record
ord-81700aa1cbf04c4e805af138f2815386
Source dataset
uspto-grants-2006_06
Patent number
US07057043B2

Reaction notes

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