1-(2-Fluorophenyl)piperazine → HCID 10042062, compound

HRID 1828273Notes

Reaction equation

HRID 1828273 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10]O.CS(OS(C)(=O)=O)(=O)=O.CCN(C(C)C)C(C)C.[F:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10][N:40]1[CH2:39][CH2:38][N:37]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[F:30])[CH2:42][CH2:41]1

Participants

5

Reactant 4

HCID 705291-(2-Fluorophenyl)piperazineHCID 81531DiisopropylethylamineHCID 81560Methanesulfonic anhydrideHCID 27763352-(Hydroxymethyl)benzo[b]thiophene

Product 1

HCID 10042062HCID 10042062, compound

Procedure

The product from Example 8A (150 mg 0.9 mmol), methane sulfonic anhydride (159 mg, 0.9 mmol), and DIEA (475 μL 2.7 mmol) were combined. After stirring, 1-(2-fluorophenyl)piperazine (181 mg, 1.0 mmol) was also combined and processed as described in Example 8B to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ 2.63 (m, 4H) 3.04 (m, 4H) 3.86 (s, 2H) 7.04 (m, 6H) 7.32 (m, 2H) 7.77 (m, 1H). (ESI) m/z 327 (M+H)+.

Sources & evidence

ORD record
ord-308512e7aaf942829b81c622472c3fd3
Source dataset
uspto-grants-2006_06
Patent number
US07057042B2

Reaction notes

Loading…