Trifluoroacetic acid → HCID 22063571, compound

HRID 1828526Notes

Reaction equation

HRID 1828526 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:32]=[CH:31][N:14]3[C:15](=[O:30])[C:16](/[CH:21]=[CH:22]/[C:23]([O:25]C(C)(C)C)=[O:24])=[C:17]([O:19][CH3:20])[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].FC(F)(F)C(O)=O>>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:32]=[CH:31][N:14]3[C:15](=[O:30])[C:16](/[CH:21]=[CH:22]/[C:23]([OH:25])=[O:24])=[C:17]([O:19][CH3:20])[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588147HCID 86588147, compound

Product 1

HCID 22063571HCID 22063571, compoundYield 122.6%

Procedure

The tert-butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-methoxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate (6.7 mg) obtained in (A) was treated with trifluoroacetic acid (0.5 ml) in the dark for 30 minutes, and then the solvent was evaporated. The residue was added with methanol and methylene chloride, and insoluble matters were collected by filtration to obtain the title compound (7.2 mg).

Workup

  1. customthe solvent was evaporated
  2. additionThe residue was added with methanol and methylene chloride, and insoluble matters
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-a9bb831b762a489f98f96133574d9ada
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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